Malegra FXT Plus contains two active ingredients: Sildenafil citrate (for erectile dysfunction) and Fluoxetine (an antidepressant that helps with premature ejaculation). This combination can interact with nitrates, leading to serious health risks. Reasons for Interaction with Nitrates: Sildenafil and Nitrates: Sildenafil, the key component of Malegra FXT Plus, is a PDE5 inhibitor. It works by relaxing blood vessels and increasing blood flow to the penis. Nitrates, commonly used to treat angina (chest pain) and heart conditions, also work by dilating blood vessels. When Sildenafil and nitrates are taken together, they can cause an excessive drop in blood pressure. This can lead to symptoms such as dizziness, fainting, Malegra FXT Plus attack, or even stroke. The combined vasodilatory effects are dangerous and should be avoided at all costs. Fluoxetine and Nitrates: While Fluoxetine doesn’t have a direct interaction with nitrates, it can cause side effects like dizziness and low blood pressure, which can compound the blood pressure-lowering effect when combined with nitrates and Sildenafil. Common Nitrates Include: Nitroglycerin (used in sublingual tablets, sprays, or patches) Isosorbide dinitrate Isosorbide mononitrate These medications are often prescribed for heart conditions and must not be taken with Malegra FXT Plus. Conclusion: Malegra FXT Plus interacts dangerously with nitrates because both Sildenafil and nitrates significantly lower blood pressure when combined.