How many calories do you burn running a mile is a fantastic workout that offers both physical and mental benefits. The number of calories burned during this exercise depends on several factors, including your weight, speed, and running efficiency. On average, a person weighing around 150 pounds can burn approximately 100 to 125 calories when running a mile at a moderate pace (around 5 miles per hour). However, faster running speeds and higher body weights can result in burning more calories, sometimes up to 150 calories per mile. Running is an excellent way to stay fit, burn calories, and enjoy the great outdoors!